Dimethoxytriyl (DMTCl44)ʻO ia ka mea ikaika a me ka versatile pūhui i hoʻohana nui ʻia i ka kemika organik ma ke ʻano he mea hoʻomalu pūʻulu kūpono, eliminating agent, a me hydroxyl protecting agent no nā nucleosides a me nā nucleotides.ʻO kāna mau waiwai kūʻokoʻa a me nā noi like ʻole ua lilo ia i mea pono pono i ke kahua o ka synthesis kemika.
ʻO DMTCl44, me ke ʻano kemika C28H23Cl2NO2, ʻike mau ʻia ʻo Dimethoxytrityl chloride.Loaʻa iā ia kahi helu CAS o 40615-36-9 a mahalo nui ʻia no kona hiki ke pale a hana i nā pūʻulu hana like ʻole, no laila e hiki ai i ka synthesis o nā molekala paʻakikī me ka pololei a me ka pono.
ʻO kekahi o nā hiʻohiʻona nui oDMTCl44ʻO kona hiki ke pale i nā pūʻulu hydroxyl, ʻoi loa i nā nucleosides a me nā nucleotides.He mea koʻikoʻi kēia mau pūhui i ka DNA a me RNA synthesis, a he mea koʻikoʻi ko lākou pale i mea e mālama ai i ko lākou kūpaʻa i ka wā o nā loli kemika.Mālama maikaʻi ʻo DMTCl44 i ka pūʻulu hydroxyl, pale i nā hopena i makemake ʻole ʻia a ʻae i nā hoʻololi koho e hana i nā hui hana ʻē aʻe.
Eia kekahi, lawelawe ʻo DMTCl44 ma ke ʻano he mea hoʻopau maikaʻi a i ʻole deprotecting agent.Hoʻomaʻamaʻa ia i ka wehe ʻana i nā pūʻulu pale i ka wā i loaʻa ai nā hoʻololi kemika i makemake ʻia.He mea koʻikoʻi kēia hiʻohiʻona i ka synthesis multi-step, kahi e pono e wehe ʻia nā hui pale e wehe i nā wahi reactive no ka hoʻololi hou ʻana.ʻO ka hiki o DMTCl44 ke hoʻopau i nā pūʻulu pale ma ke koho a me ka maikaʻi ua hoʻololi i ke kahua o ka kemika organik, hiki i nā mea noiʻi ke ʻimi i nā ala synthetic paʻakikī a hoʻomohala i nā molekala hou me nā hana biological i hoʻonui ʻia.
ʻO nā hopena hoʻololi i hoʻoikaika ʻia e DMTCl44 he nui.Hoʻohana nui ʻia ia i ka synthesis o ka nucleoside a me ka nucleotide analogs, he mea nui i ka ʻike ʻana a me ka hoʻomohala ʻana i ka lāʻau.Ma ka pale ʻana i nā pūʻulu hana kikoʻī, hiki i nā mea kemika ke hoʻopololei i ka reactivity o kēia mau pūhui e hana i nā analogs hou me nā waiwai pharmacological i hoʻomaikaʻi ʻia.ʻO ke kuleana o DMTCl44 ma ke ʻano he mea hoʻomalu hydroxyl he mea koʻikoʻi i kēia mau kaʻina, no ka mea e hōʻoiaʻiʻo i ka mālama ʻana i ka hana biological makemake ʻoiai e ʻae ana i nā hoʻololi i nā kūlana ʻē aʻe.
DMTCl44loaʻa pū kekahi i ka pono i ka peptide synthesis, ʻoi loa i ka pale ʻana i nā waikawa amino i ka wā solid-phase peptide synthesis.Loaʻa i nā ʻakika amino he mau pūʻulu hana reactive hiki ke alakaʻi i nā hopena ʻaoʻao makemake ʻole i ka wā o ka synthesis.Ma ka hoʻohana ʻana i ka DMTCl44 ma ke ʻano he hui pale pale, hiki i nā chemists ke hoʻomalu i ka reactivity a koho i ka pale ʻana i nā pūʻulu hana kūikawā, e hiki ai i ka hui stepwise o nā peptides me ka maʻemaʻe kiʻekiʻe a me ka hua.
Ma waho aʻe o kāna mau noi ma ke kahua o ka synthesis, ua kōkua ʻo DMTCl44 i nā holomua koʻikoʻi i ka kemika organik.ʻO kona hoʻohana ʻana ma ke ʻano he pūʻulu pale i ʻae i ka hoʻomohala ʻana a me ka synthesis o nā huahana kūlohelohe like ʻole, nā lāʻau lapaʻau, a me nā moleke bioactive.Ua wehe ʻo ia i nā ala hou no ka hoʻolālā a me ka synthesis o nā lāʻau lapaʻau hou, nā ʻōnaehana catalytic, a me nā mea hana.
I ka hopena,Dimethoxytriyl (DMTCl44)ua puka mai ma ke ʻano he mea pono loa i ka honua o ka kemika organik.ʻO kāna hana ma ke ʻano he hui pale palekana, eliminating agent, a me hydroxyl protecting agent i kōkua nui i ka holomua o nā hopena kemika a me ka hoʻomohala ʻana i nā molekala hou.ʻO kāna mau waiwai kūʻokoʻa a me kāna mau noi maʻalahi e lilo ia i mea reagent koʻikoʻi ma nā ʻano āpau, me nā lāʻau lapaʻau, biochemistry, a me nā ʻepekema waiwai.Ke ʻimi nei ka poʻe noiʻi i ka hohonu o ka honua hoihoi o DMTCl44, ʻoiaʻiʻo e ʻike hou ʻia nā hopena hoʻololi hou a me nā noi hou, e koi hou ana i nā palena o ke kemika organik.
Ka manawa hoʻouna: Sep-26-2023